Table 1. The inhibitory activity of the compounds against RIP3 and Rafs.

Compounds	IC50 for RIP3 (μM)		IC50 for Rafs (nM)
	Luminescent assaysa	Radioactive assaysa	B-Raf	B-RafV600E	C-Raf	Refsb
Dabrafenib	0.25±0.16	0.002	3.2	0.8	5.0	35
AZ628	0.90±0.15	4.48	100	34	29	36
Regorafenib	2.56±1.02	0.95	28	19	—c	37
PLX4720	4.72±2.25	1.52	—	13	—	38
Vemurafenib	6.73±3.72	14.30	100	31	48	39
Sorafenib	14.52±0.51	NAd	22	—	—	40
GDC-0879	NA	ND	—	0.13	—	41
SB590885	NA	ND	0.16	—	1.72	42
SU11248	NA	ND	—	—	—
Necrostatin-1	NA	NA	—	—	—

Abbreviations: NA, not applicable; ND, not determined; RIP, receptor-interacting protein

^aIC₅₀ values from luminescent assays were presented as mean±S.D. from three independent experiments in our laboratory, whereas the IC₅₀ values from radioactive assays were presented as the mean of two independent experiments performed by the Reaction Biology Corporation

^bReferences (refs) reporting the IC₅₀ values of Rafs inhibition by the corresponding compounds

^cNo data reported

^dNo IC₅₀ available at the tested conditions