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. 2014 Jun 12;5(6):e1291. doi: 10.1038/cddis.2014.251

Figure 4.

Figure 4

ABT-737 treatment induced mitotic cell death under mitotic arrest. (a) Fate profiles of MDA-MB-231 cells treated with either DMSO or ABT-737, and treated or not with paclitaxel. MDA-MB-231 cells were infected with H2B-RFP-coding lentivectors and treated with either DMSO or ABT-737 (1 μM). Cells were then synchronized using a double thymidine block, treated with either DMSO or paclitaxel (70 nM), and finally analyse by time-lapse videomicrocopy during 72 h. Data for 50 cells per condition are presented. Time 0 represents the time of addition of paclitaxel. (b) End-point cell fates of MDA-MB-231 cells treated or not with paclitaxel and ABT-737. The proportion of each fate at the end point of experiments (72 h) derived from data presented in Figure 5a are shown in pie charts and % of cell fates in the associated table (UL=upper left, UR=upper right, LL=lower left and LR=lower right, corresponding panels in a)