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. 2014 Jun 12;5(6):e1289. doi: 10.1038/cddis.2014.253

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Expression of Dyrk1a and the levels of phosphorylated Casp9 in the ventral mesencephalon of adult mBACtgDyrk1a (BACD1a) mice. (a) Confocal images showing a similar Dyrk1a distribution in the SN of 8-week-old (8W) wild-type (WT) and BACD1a mice. Bar=100 μm. (b) Representative western blottings and their quantifications showing the levels of Dyrk1a (D1a) normalized to the amount of Vinculin (Vinc), and the proportion of Casp9 that is Thr125 phosphorylated (P(Thr125)) in total mesencephalic extracts prepared from 12- to 16-week-old WT and BACD1a littermates. Histogram values are the mean±S.E.M. *P≤0.05 (n=5)