Figure 1.

Plm-IV localization assay. (a) Confocal microscopy images show that Plm-IV co-localizes with the dark hemozoin-containing DV in healthy 3D7 P. falciparum parasites but not in (b) parasites treated with 3 μM of CQ for 4 h, where Plm-IV staining is less intense and is found throughout the parasite cytoplasm. (Scale bar set at 5 μm). (c) The number of parasites counted and respective percentages, with and without CQ-treatment, and as represented in (d) histogram form, shows a clear redistribution of Plm-IV out of the DV into the cytoplasm