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. 2014 Jun 26;5(6):e1300. doi: 10.1038/cddis.2014.268

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Copyright © 2014 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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IGFBP7 induces a G2/M cell cycle block and apoptosis in AML cells. (a) Cell cycle distribution analysis (left panel) of Kasumi-1 control cells or with overexpression of IGFBP7. The frequency of cells in the G1, S and G2 phases of the cell cycle was determined (right panel). (b) Kasumi-1 cells with or without the overexpression of IGFBP7 were cultured for 72 h under low-serum conditions and Annexin-V positivity was measured using flow cytometry (left panel). Annexin-V positivity after overexpression of IGFBP7 in Kasumi-1 of n=2 (right panel). (c) NB4 cells were cultured in Opti-Mem reduced serum medium with 1% FSC in the presence of rhIGFBP7. Apoptosis was detected by establishing Annexin-V and 7-AAD positivity using flow cytometry