Table 1.
Displays the most commonly described CD4+ restricted epitopes
| Amino acid position | HCV protein | Amino acid sequence | HLA-restriction | Reference |
| aa 21-40 | Core | DVKFPGGGQIVGGVYLLPRR | DRB1*1101,DQB1*0301 | Day, 2002 |
| aa 31-45 | Core | VGGVYLLPRR GPRLG | DRB1*1101 | Godkin, 2001 |
| aa 141-155 | Core | GAPLGGAARA LAHGV | DRB1*1101 | Godkin, 2001 |
| aa 393-410 | E2 | GFATQRLTSLFALGPSQK | DRB1*1101 | Frasca, 1999 |
| aa 1241-1260 | NS3 | PAAYAAQGYKVLVLNPSVAA | DRB1*15, DRB1*0301 + | Day, 2002 |
| aa 1248-1261 | NS3 | GYKVLVLNPSVAAT | DR4, DRB1*1101 | Wertheimer, 2003 |
| aa 1248-1267 | NS3 | GYKVLVLNPSVAATLGFGAY | DQB1*0301 | Lamonaca, 1999 |
| aa 1251-1259 | NS3 | VLVLNPSVA | DRB1*1101,DRB1*1201, DRB1*0401, DRB1*1302 | Day, 2002 |
| aa 1384-1401 | NS3 | VIKGGRHLIFCHSKKKCD | DRB1*15 | Eckels. 1999 |
| aa 1411-1426 | NS3 | GINAVAYYRGLDVSVI | DRB1*15 | Gerlach, 2005 |
| aa 1531-1550 | NS3 | TPAETTVRLRAYMNTPGLPV | DRB1*0701 | Day, 2002 |
| aa 1539-1554 | NS3 | LRAYMNTPGLPVCQDH | DRB1*15 | Gerlach, 2005 |
| aa 1581-1600 | NS3 | ENLPYLVAYQATVCARAQAP | DRB1*1001 | Day, 2002 |
| aa 1686-1705 | NS4a | VVLSGKPAIIPDREVLYREF | DRB1*0301 | Harcourt, 2003 |
| aa 1746-1765 | NS4b | IAPAVQTNWQKLETFWAKHM | DRB1*16 or DRB3*0202 | Harcourt, 2003 |
| aa 1767-1786 | NS4b | NFISGIQYLAGLSTLPGNPA | DRB1*1104 | Carlos, 2004 |
| aa 1771-1790 | NS4b | GIQYLAGLSTLPGNPAIASL | DRB1*0404 | Day, 2002 |
| aa 1806-1818 | NS4b | TLLFNILGGWVAA | DRB1*0101 | Gerlach, 2005 |
| aa 1907-1926 | NS4b | GPGEGAVOWMNRLIAFASRG | DRB1*1104,DQB1*0501 | Lamonaca, 1999 |
| aa 2268-2282 | NS5a | VSVPAEILRK SRRFA | DRB1*1101 | Godkin, 2001 |
| aa 2571-2590 | NS5b | KGGRKPARLIVFPDLGVRVC | DRB1*0404,DRB1*0407 | Day, 2002 |
| aa 2841-2860 | NS5b | ARMILMTHFFSVLIARDQLE | DRB1*1101 | Day, 2002 |
| aa 2941-2955 | NS5b | CGKYLFNWAV RTKLK | DRB1*1101 | Godkin, 2001 |
| aa 2941-2960 | NS5b | CGKYLFNWAVRTKLKLTPIA | DRB1*1101 | Day, 2002 |