Table 1. Baseline parameter values and range of variation analysed.
Parameter | Description | Baseline Value | Considered range |
---|---|---|---|
Disease related | |||
1/γ | Mean duration of infectiousness | 1 month | Fixed |
l | Relative duration of latency compared to the infectiousness duration | 2 | 10−10 − 100 |
R0 | Basic reproductive number | 2 | 1 − 5 |
b | Relative hazard of secondary infection | 1 | 0 − 2 |
σ | Infection-relative death rate | 0 | 0 − 0.1 (/person/month) |
Vaccine related | |||
α | Vaccine efficacy | 0.7 | 0 − 1 |
f | Vaccine coverage | 0.5a | 0 − 1a |
i | Proportion of vaccinated individuals totally immunized | 0 | 0 − αb |
c | Relative infectiousness of vaccinated infectious individuals | 1 | 0 − 1 |
Demographic | |||
μ | Natural annual death rate | 16/1 000 persons/year i.e. 62.5 years life expectancy | Fixed |
aVaccine coverage used for the post-vaccination phase, as this is null in the pre-vaccine phase.
bThe proportion of individuals completely protected after vaccination cannot exceed vaccine efficacy.