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. 2015 Oct 20;5:15356. doi: 10.1038/srep15356

Figure 1. Histidine provides neuroprotection on the neurological function and cognitive abilities after focal cerebral ischemia.

Figure 1

Neurological scores were evaluated on 1 d, 3 d, 7 d after ischemia under the treatment of histamine (A, 200, 500 or 1000 mg/kg), and evaluated on 14 d, 28 d, 42 d, 56 d after ischemia under the treatment of histidine treatment (B, 1000 mg/kg for the first week but 0, 200, 500, or 1000 mg/kg for later weeks, named as His 1000–0, His 1000–200, His 1000–500 or His 1000–1000). Cognitive abilities were examined by Morris water maze (D: Day 22–24; F: Day 50–52) and contextual and cued fear conditioning test (E: Day 27, G: Day 55) after ischemia. The representative swim paths on Day 24 in (D) were shown in (C), and the gray circle indicates the location of the platform. n = 13–15 for A,B (Day 14 and Day 28), D and E; n = 7–9 for B (Day 42 and Day 56), F and G. *P < 0.05, **P < 0.01, ***P < 0.001, compared with sham group within each test day or each test, #P < 0.05, ##P < 0.01, ###P < 0.001, compared with tMCAO group within each test day or each test.