Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Oct 20;6:164. doi: 10.3389/fendo.2015.00164

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Tharp and Stahl.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Beige adipose tissue-matrix-assisted cellular transplant (BAT-MACT). The strategy used to expand beige adipose tissue for therapeutic purposes can be deconstructed into six stages: (1) Isolation of white adipose tissue (WAT) from patient. (2) Purification of stromal vascular fraction from the explanted WAT. (3) In vitro differentiation of SVF-derived preadipocytes toward the beige fat phenotype. (4) Suspension of beige adipocytes (SVF) into optimized hydrogel for implantation. (5) Post implantation, the hydrogel is biocompatible and degradable so that it is permissive to integrate the recipient’s vascular, immune, and nervous systems. (6) The established beige adipose tissue functions as a metabolically active organ. If a sufficient increase of metabolic rate is achieved via BAT-MACT implantation, weight loss will occur.