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. 2015 Oct 20;6:222. doi: 10.3389/fneur.2015.00222

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Copyright © 2015 Turner, Lucke-Wold, Logsdon, Robson, Dashnaw, Huang, Smith, Huber, Rosen and Petraglia.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Tau conformational markers were increased throughout the contralateral superficial cortex. PHF was significantly increased at 1-month post repetitive blast (t = 6.055, p < 0.001). CP-13 staining was also significantly increased following repetitive blast (t = 3.883, p < 0.01). CP-13 was increased in a perivascular distribution. Tau conformational change is required for the formation of neurofibrillary tangles. Values were calculated using a student’s t-test comparing the mean difference between groups.