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Removal of Hinfp causes reduction of histone H4 mRNA levels in both cKO and dKO cells. Quantitative PCR analysis of relative mRNA levels was performed for different histone genes in both cKO and dKO cells. (A) RNAs for 2 Hinfp-dependent histone H4 genes, Hist1H4m and Hist2H4 are reduced after Hinfp ablation, (B) Other core and linker histones upon Hinfp-mediated histone H4 depletion show transient increases in expression levels. (Hist1H1a, Hist1H3i, H2a, H2b).
