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Reducing p21 is not sufficient to activate apoptosis in p53 deficient cells depleted of stathmin or pulsed for 4 hrs with a CDK1 inhibitor. (A) Western blot of p21 depletion from Hela cells. Tubulin is shown as a loading control. (B) Percent trypan blue positive cells for the indicated conditions measured 48 hr after transfection of inhibitor pulse.
