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. Author manuscript; available in PMC: 2015 Oct 21.
Published in final edited form as: J Pathol. 2014 Mar 31;233(2):148–158. doi: 10.1002/path.4334

Figure 3. Differential effects of Fgfr3 and Pten mutations in regulation of urothelial cell size and proliferation.

Figure 3

The cell size of was analysed comparing cells in each layer using immunohistochemistry with E-cadherin. The sizes of cells in the outermost umbrella (a) and innermost basal (c) cell layers did not show any significant differences among the cohorts. However increase in cell size was observed in the intermediate (between the inner and outmost) layer, in particular in UroIICrePtenflox/flox and in UroIICre Fgfr3+/K644EPtenflox/flox (b). Ki67-positive cells were increased in the urothelium of UroIICrePtenflox/flox as well as UroIICreFgfr3+/K644EPtenflox/flox mice, comparing to other cohorts (d). The error bars indicate the standard deviations.