Figure 3.

Factors affecting aged mitochondria. Numerous biological processes modulate mitochondrial function. Defects in mitochondria maintenance and turnover because of impaired biogenesis and/or defective removal are thought to contribute to the pathogenesis of complex diseases and aging. The assembly and maintenance of respiratory complexes that can sustain a high energetic flux without generating excessive ROS, and the quantity and quality of energetic fuel are essential to health and successful aging.