Table 3.
Genomic comparison between NAC-responders and non-responders. Enriched KEGG pathways in non-responders with shrinkage rates ≦ 50 %
| KEGG pathway | Number of genes | NES | p-value | q-value |
|---|---|---|---|---|
| Metabolism-related | ||||
| METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 | 34 | 2.021684 | <0.01 | <0.001 |
| DRUG_METABOLISM_CYTOCHROME_P450 | 36 | 1.987058 | <0.01 | 0.002063 |
| PROPANOATE_METABOLISM | 29 | 1.925244 | <0.01 | 0.001375 |
| VALINE_LEUCINE_AND_ISOLEUCINE_DEGRADATION | 41 | 1.920898 | <0.01 | 0.001179 |
| BUTANOATE_METABOLISM | 26 | 1.873636 | <0.01 | 0.003011 |
| GLUTATHIONE_METABOLISM | 42 | 1.652794 | <0.01 | 0.031592 |
| DNA repair system-related | ||||
| MISMATCH_REPAIR | 21 | 1.935372 | <0.01 | 0.00165 |
| HOMOLOGOUS_RECOMBINATION | 23 | 1.754282 | <0.01 | 0.009237 |
| BASE_EXCISION_REPAIR | 33 | 1.62332 | <0.01 | 0.041855 |
| NUCLEOTIDE_EXCISION_REPAIR | 42 | 1.588174 | <0.01 | 0.042931 |
| Others | ||||
| DNA_REPLICATION | 33 | 2.245259 | <0.01 | <0.001 |
| CELL_CYCLE | 107 | 2.148499 | <0.01 | <0.001 |
| ALDOSTERONE_REGULATED_SODIUM_REABSORPTION | 25 | 1.668492 | 0.019608 | 0.027948 |
| GLYCOSYLPHOSPHATIDYLINOSITOL_GPI_ANCHOR | 23 | 1.597785 | 0.017544 | 0.042713 |
KEGG Kyoto Encyclopedia of Genes and Genomes Database, NES Normalized Enrichment Score