Table 4.
Association between UGT1A1 genotypes and either prognostic factors or Grade 3 to 4 toxicities (n = 23)
| UGT1A1 genotypes | *1/*6 or*1/*28 | *1/*1 | p |
|---|---|---|---|
| n = 11 | n = 12 | ||
| Prognostic factors | |||
| LVSI | 5 (45 %) | 6 (50 %) | 0.827 |
| Shrinkage rate (median +/− SD %) | 77.5 +/− 26.8 | 49.5 +/− 24.1 | 0.028* |
| G3/4 Toxicities | |||
| Neutropenia | 6 (54.5 %) | 8 (66.7 %) | 0.552 |
| Leukopenia | 4 (36.4 %) | 3 (25.0 %) | 0.554 |
| Anemia | 2 (18.2 %) | 1 (8.3 %) | 0.484 |
| Thrombocytopenia | 1 (9.1 %) | 0 | 0.286 |
| Diarrhea | 2 (18.2 %) | 1 (8.3 %) | 0.484 |
| Vomiting | 1 (9.1 %) | 0 | 0.286 |
*significant p-value