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. 2015 Oct 19;15:736. doi: 10.1186/s12885-015-1687-x

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© Kalmár et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Heatmap representing level of DNA methylation in a) NAT, AD, and CRC biopsies and macrodissected samples and in b) NAT, AD and CRC LCM epithelial cells. Intensity values on the colour scale were as follows: red - high intensity, black - intermediate intensity, green - low intensity. Samples are shown in columns, selected genes are in rows. Similar DNA methylation pattern could be found in both sample types, as PRIMA1, SFRP1, SFRP2, MAL, SOCS3, CYP27B1, COL1A2 and SULT1A1 showed relatively high DNA methylation levels in colon biopsies and LCM epithelial cells