Table 2.
Gene expression data of biopsies and laser microdissected (LCM) colon epithelial cells
| Normal | Adenoma | CRC | P-value (N vs. Ad) | P-value (N vs. CRC) | P-value (Ad vs. CRC) | |
|---|---|---|---|---|---|---|
| Mean normalised intensity values ± SD | Mean normalised intensity values ± SD | Mean normalised intensity values ± SD | ||||
| Biopsy samples | ||||||
| 203180_at (ALDH1A3) | 6.36 ± 0.92 | 6.53 ± 0.86 | 7.29 ± 1.45 | 0.34 | p < 0.01 | p < 0.01 |
| 203685_at (BCL2) | 8.90 ± 0.52 | 7.96 ± 1.08 | 6.98 ± 1.22 | p < 0.01 | p < 0.01 | p < 0.01 |
| 206430_at (CDX1) | 11.70 ± 0.28 | 11.17 ± 0.35 | 10.84 ± 0.73 | p < 0.01 | p < 0.01 | p < 0.01 |
| 202404_s_at (COL1A2) | 9.75 ± 0.78 | 10.25 ± 1.11 | 12.31 ± 1.67 | 0.01 | p < 0.01 | p < 0.01 |
| 205676_at (CYP27B1) | 2.55 ± 0.10 | 2.88 ± 0.54 | 3.15 ± 0.95 | p < 0.01 | p < 0.01 | 0.09 |
| 1554094_at (ENTPD5) | 6.41 ± 0.70 | 4.56 ± 0.79 | 4.15 ± 1.29 | p < 0.01 | p < 0.01 | 0.06 |
| 208963_x_at (FADS1) | 4.82 ± 0.70 | 5.05 ± 1.14 | 6.36 ± 1.65 | 0.22 | p < 0.01 | p < 0.01 |
| 204777_s_at (MAL) | 6.02 ± 0.62 | 4.86 ± 0.37 | 4.88 ± 0.59 | p < 0.01 | p < 0.01 | 0.86 |
| 230087_at (PRIMA1) | 4.09 ± 0.97 | 2.20 ± 0.61 | 2.31 ± 0.83 | p < 0.01 | p < 0.01 | 0.47 |
| 234165_at (PTGDR) | 5.84 ± 1.08 | 3.91 ± 1.75 | 2.81 ± 0.85 | p < 0.01 | p < 0.01 | p < 0.01 |
| 204748_at (PTGS2) | 4.96 ± 1.33 | 6.84 ± 2.50 | 9.88 ± 2.74 | p < 0.01 | p < 0.01 | p < 0.01 |
| 202036_s_at (SFRP1) | 4.05 ± 1.47 | 2.18 ± 0.62 | 2.51 ± 1.28 | p < 0.01 | p < 0.01 | 0.11 |
| 223121_s_at (SFRP2) | 2.87 ± 0.11 | 2.92 ± 0.28 | 3.94 ± 1.74 | 0.29 | p < 0.01 | p < 0.01 |
| 227697_at (SOCS3) | 6.10 ± 1.11 | 7.42 ± 1.65 | 9.81 ± 2.06 | p < 0.01 | p < 0.01 | p < 0.01 |
| 212353_at (SULF1) | 6.29 ± 1.04 | 7.12 ± 1.16 | 9.23 ± 2.15 | p < 0.01 | p < 0.01 | p < 0.01 |
| 215299_x_at (SULT1A1) | 11.94 ± 0.53 | 10.40 ± 0.85 | 10.34 ± 0.95 | p < 0.01 | p < 0.01 | 0.72 |
| 203083_at (THBS2) | 2.61 ± 0.44 | 3.46 ± 1.54 | 7.67 ± 3.13 | p < 0.01 | p < 0.01 | p < 0.01 |
| 201666_at (TIMP1) | 10.29 ± 0.75 | 12.20 ± 0.69 | 12.80 ± 1.04 | p < 0.01 | p < 0.01 | p < 0.01 |
| LCM - colon epithelial cells | ||||||
| 203180_at (ALDH1A3) | 3.44 ± 0.83 | 3.35 ± 0.34 | 3.61 ± 0.73 | 0.80 | 0.72 | 0.45 |
| 203685_at (BCL2) | 7.02 ± 0.64 | 6.94 ± 1.56 | 4.52 ± 2.00 | 0.91 | p < 0.05 | p < 0.05 |
| 206430_at (CDX1) | 10.35 ± 0.57 | 9.51 ± 0.47 | 9.38 ± 0.53 | p < 0.05 | p < 0.05 | 0.65 |
| 202404_s_at (COL1A2) | 4.27 ± 1.50 | 3.28 ± 0.69 | 7.55 ± 1.02 | 0.18 | p < 0.01 | p < 0.01 |
| 205676_at (CYP27B1) | 2.75 ± 0.04 | 2.79 ± 0.05 | 3.07 ± 0.24 | 0.10 | p < 0.01 | p < 0.05 |
| 1554094_at (ENTPD5) | 4.51 ± 0.68 | 3.80 ± 0.69 | 2.51 ± 0.08 | 0.10 | p < 0.01 | p < 0.01 |
| 208963_x_at (FADS1) | 3.24 ± 0.21 | 3.18 ± 0.17 | 4.44 ± 1.49 | 0.57 | 0.08 | 0.07 |
| 204777_s_at (MAL) | 2.38 ± 0.17 | 2.30 ± 0.00 | 2.31 ± 0.02 | 0.29 | 0.34 | 0.30 |
| 230087_at (PRIMA1) | 2.63 ± 0.29 | 3.88 ± 1.08 | 2.43 ± 0.12 | p < 0.05 | 0.14 | p < 0.01 |
| 234165_at (PTGDR) | 4.71 ± 0.73 | 3.77 ± 1.02 | 2.39 ± 0.09 | 0.10 | p < 0.01 | p < 0.01 |
| 204748_at (PTGS2) | 2.61 ± 0.15 | 2.68 ± 0.24 | 2.51 ± 0.04 | 0.59 | 0.14 | 0.13 |
| 202036_s_at (SFRP1) | 2.71 ± 0.35 | 2.76 ± 0.33 | 2.54 ± 0.00 | 0.80 | 0.27 | 0.13 |
| 223121_s_at (SFRP2) | 2.35 ± 0.09 | 2.36 ± 0.16 | 2.30 ± 0.00 | 0.81 | 0.28 | 0.34 |
| 227697_at (SOCS3) | 4.97 ± 1.91 | 2.82 ± 0.43 | 4.33 ± 1.69 | p < 0.05 | 0.55 | 0.06 |
| 212353_at (SULF1) | 3.08 ± 0.81 | 2.73 ± 0.09 | 3.99 ± 1.44 | 0.32 | 0.21 | 0.06 |
| 215299_x_at (SULT1A1) | 9.35 ± 0.31 | 8.57 ± 1.16 | 7.20 ± 0.95 | 0.14 | p < 0.01 | p < 0.05 |
| 203083_at (THBS2) | 2.58 ± 0.14 | 2.53 ± 0.00 | 3.54 ± 1.43 | 0.48 | 0.13 | 0.12 |
| 201666_at (TIMP1) | 4.11 ± 1.06 | 6.54 ± 1.62 | 7.85 ± 0.57 | p < 0.05 | p < 0.01 | 0.09 |