Table 2.

Subhazard ratios (95% CI) for CVD and non-CVD mortality per third of each biomarker distribution.

Biomarker	CVD mortality subhazard ratio (95% CI)		Non-CVD mortality subhazard ratio (95% CI)		P (CVD versus non-CVD)
Troponin	1.71a	(1.46–1.99)⁎⁎	1.00a	(0.89–1.11)	< 0.001
BNP	1.54a	(1.34–1.78)⁎⁎	0.99	(0.89–1.10)	< 0.001
Plasma viscosity	1.30	(1.13–1.50)⁎⁎	1.20	(1.08–1.34)⁎⁎	0.49
White cell count	1.28	(1.11–1.48)⁎⁎	1.07	(0.96–1.19)	0.10
GDF-15	1.25	(1.07–1.45)⁎	1.35	(1.20–1.53)⁎⁎	0.53
IL-6	1.24a	(1.08–1.43)⁎	1.38	(1.24–1.54)⁎⁎	0.38
Total cholesterol	1.20	(1.05–1.37)⁎	0.81	(0.72–0.90)⁎⁎	< 0.001
Fibrinogen	1.19	(1.05–1.36)⁎	1.08	(0.98–1.20)	0.32
VCAM	1.19	(1.03–1.36)	1.01	(0.91–1.12)	0.10
Cystatin-C	1.19b	(1.02–1.38)	1.09	(0.98–1.21)	0.43
PAPP-A	1.16	(1.01–1.32)	0.97	(0.87–1.08)	0.07
E-selectin	1.15c	(0.99–1.32)	1.12	(1.01–1.24)	0.81
C-RP	1.12	(0.98–1.29)	1.22	(1.09–1.36)⁎⁎	0.42
Alkaline phosphatase	1.09	(0.96–1.24)	1.27	(1.14–1.41)⁎⁎	0.13
Glucose	1.09	(0.95–1.25)	1.13	(1.02–1.26)	0.70
Triglycerides	1.07	(0.93–1.22)	1.00	(0.90–1.11)	0.46
Uric acid	1.05	(0.91–1.21)	1.11	(0.99–1.23)	0.61
Fetuin-A	1.04	(0.91–1.18)	1.09	(0.98–1.21)	0.58
IL-6 receptor	1.02	(0.90–1.16)	1.00	(0.91–1.11)	0.85
Lp-a	0.99	(0.87–1.13)	1.01	(0.91–1.12)	0.82
GGT	0.98	(0.84–1.13)	1.24	(1.11–1.38)⁎⁎	0.02
RBP-4	0.95	(0.83–1.09)	0.85	(0.77–0.95)⁎	0.20
Vitamin B6	0.95	(0.83–1.09)	0.83	(0.75–0.93)⁎	0.10
Ferritin	0.93	(0.81–1.06)	1.05	(0.95–1.17)	0.13
Alanine transaminase	0.92	(0.81–1.06)	1.07	(0.96–1.19)	0.09
Creatinine	0.90	(0.80–1.03)	1.04	(0.94–1.14)	0.08
Aspartate transaminase	0.89b	(0.77–1.02)	1.10	(0.99–1.21)	0.01
Glutamate dehydrogenase	0.84	(0.70–1.01)	1.06	(0.92–1.23)	0.03

^aEvidence of departure from proportional subhazards assumption (P < 0.01).

^bEvidence of non-linearity in the relationship between biomarker and mortality (P < 0.01).

^cEvidence of biomarker interaction with prior CVD (P < 0.01).

^⁎P < 0.01.

^⁎⁎P < 0.001.