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Schematic of TRIM31 within a TRIM-MAGE-NSE4 complex. NSE3-related stimulation of NSE1 E3 ligase activity within the NSE1-NSE3-NSE4 complex is WH-A-binding-dependent; model for MAGEA1-TRIM31-NSE4 enhancement of ubiquitination, mediated by WH-A and Coiled-coil recognition; alternative TRIM-MAGE mode of binding through C-terminus and WH-B. How co-factors (C), substrates (S) and E2 enzymes fit into the model is still unclear.
