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The tumor suppressor p53 is not a direct repressor of transcription, it solely activates its target genes upon binding to DNA. In order to activate transcription, the p53 tetramer binds to the p53 RE of its target gene. The transcription factor p53 acts as repressor by activation of the p53-p21-DREAM/RB pathway ultimately leading to indirect p53-dependent transcriptional repression.
