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. Author manuscript; available in PMC: 2016 Aug 1.

Published in final edited form as: J Data Mining Genomics Proteomics. 2013 Jul 31;4(3):135. doi: 10.4172/2153-0602.1000135

Metagenomic shotgun reads from 20 blood plasma samples from febrile children were aligned to viral reference genomes at the nucleotide sequence level and compared to translated alignments generated using mBLASTX and mTBLASTX. (A) Translated alignments improve detection of ssDNA and ssRNA viruses in metagenomic samples. (B–E) Examples from 4 plasma samples from febrile children and the detected Anelloviruses (ssDNA genomes), enteroviruses (+ssRNA genomes), erythroviruses (ssDNA genomes), and dependoviruses (ssDNA genomes). The numbers of viral sequences detected by each alignment method are shown.

Metagenomic shotgun reads from 20 blood plasma samples from febrile children were aligned to viral reference genomes at the nucleotide sequence level and compared to translated alignments generated using mBLASTX and mTBLASTX. (A) Translated alignments improve detection of ssDNA and ssRNA viruses in metagenomic samples. (B–E) Examples from 4 plasma samples from febrile children and the detected Anelloviruses (ssDNA genomes), enteroviruses (+ssRNA genomes), erythroviruses (ssDNA genomes), and dependoviruses (ssDNA genomes). The numbers of viral sequences detected by each alignment method are shown.