TABLE II.
Response to Treatment by Salvage Status and IDH Mutation Status
| n | CR/CRi | P-value | Median OS | P-value | |
|---|---|---|---|---|---|
| Induction | 562 | 382 (68%) | 0.33 | 15.4 mo | 0.59 |
| IDH1+ | 37 | 24 (65) | 13.0 mo | ||
| IDH2+ | 69 | 42 (61) | 15.7 mo | ||
| IDH wild-type | 456 | 316 (69) | 15.3 mo | ||
| Salvage-1 | 120 | 50 (42%) | 0.76 | 8.7 mo | 0.44 |
| IDH1+ | 9 | 4 (40) | 5.9 mo | ||
| IDH2+ | 18 | 9 (50) | 11.1 mo | ||
| IDH wild-type | 92 | 37 (41) | 7.7 mo | ||
| ≥ Salvage-2 | 144 | 40 (27%) | 0.76 | 4.8 mo | 0.16 |
| IDH1+ | 14 | 5 (36) | 4.0 mo | ||
| IDH2+ | 19 | 5 (26) | 5.9 mo | ||
| IDH wild-type | 111 | 30 (27) | 4.8 mo |
IDH indicates isocitrate dehydrogenase; CR, complete remission; CRi, complete remission with incomplete count recovery; OS, overall survival.