(A), Core body temperature (means) during menopausal hot flashes. (B), Respiratory exchange ratio (means) during hot flashes. (C), Mean skin temperature (means) during hot flashes. (D), Sternal skin conductance (means) during hot flashes. Time 0 is the beginning of the sternal skin conductance response. Intervals between arrows are significantly different from each other at P<.05, Duncan’s test.