Skip to main content
. 2015 Aug 26;24(21):6229–6239. doi: 10.1093/hmg/ddv341

Figure 2.

Figure 2.

AAV2(quadY-F+T-V)-Ple155-mediated GFP expression (green) is restricted to ON BCs as evidenced by co-staining with either rod bipolar marker PKCα (A and C) or ON BC marker PCP2 (B) in red. Only minimal transduction was achieved via subretinal injection (A), but robust and targeted ON BC transduction was observed following P30 intravitreal injection in both WT (B) and Nyxnob mice (C). Panretinal transduction of ON BCs was observed following intravitreal injection in both strains (WT shown in D). SR = subretinal, Ivt = intravitreal, ONL = outer nuclear layer, INL = inner nuclear layer, GCL = ganglion cell layer. Scale bars = 34 μm (A–C) and 200 μm (D).