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. 2015 Aug 26;24(21):6229–6239. doi: 10.1093/hmg/ddv341

Figure 3.

Figure 3.

Intravitreal AAV2(quadY-F+T-V)-Ple155-YFP_Nyx transduction (green, GFP antibody) is restricted to ON BCs (red, PKCα antibody). Widespread ON BC transduction is observed in whole eyecups of P2-injected Nyxnob mice (A). Intraocular injection at P2 promoted robust transduction of ON BCs in both strains (Nyxnob mouse shown) (B and C). High magnification (white box) reveals YFP_NYX expression in cell bodies and dendritic tips of ON BCs (C). Minimal YFP_NYX expression was observed following intravitreal injection in P30 WT or Nyxnob mice (D and E). ONL = outer nuclear layer, INL = inner nuclear layer, GCL = ganglion cell layer. Scale bars = 17 μm (A–D) and 200 μm (E).