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. Author manuscript; available in PMC: 2015 Oct 21.
Published in final edited form as: Mult Scler Relat Disord. 2012 Jan 27;1(2):95–99. doi: 10.1016/j.msard.2011.12.003

Fig. 3.

Fig. 3

Biopsy Confirming Malignant Transformation. (a)–(d) Brain biopsy 5/07. A third brain biopsy demonstrates an increase in atypical plasma cells (arrows) with crystal laden macrophages (arrowheads) and lymphocytes (a). CD138 is positive in plasma cells with enlarged, atypical nuclei (b). Ki67 demonstrates proliferation of atypical lymphoplasmacytes with enlarged nuclei (c). Immunocytochemistry for κ-light chains highlights many lymphocytes/plasma cells (d). Findings are consistent with plasma cell neoplasm associated with CSH.