Table 3. Clearance of docetaxel as a function of the observed genotypes.
| Gene (allele) | Reference genotype | Heterozygote genotype | Variant genotype | P-valueb | |||
|---|---|---|---|---|---|---|---|
| Valuea | N | Valuea | N | Valuea | N | ||
| SLCO1B3 | |||||||
| 334T>G | 32.1 | 1 | 27.0 (15.8–36.3) | 25 | 23.2 (20.7–27.5) | 65 | 0.58 |
| 439A>G | 23.3 (20.8–27.4) | 90 | 29.7 | 1 | N/A | 0 | 0.41 |
| 699G>A | 40.1 | 2 | 27.0 (15.8–34.2) | 25 | 22.2 (19.8–26.8) | 63 | 0.22 |
| 767G>C | 22.7 (18.6–28.3) | 60 | 26.8 (21.1–31.0) | 25 | 16.0 | 4 | 0.17 |
| 1559A>C | 23.4 (20.8–27.5) | 91 | N/A | 0 | N/A | 0 | N/A |
| 1679T>C | 23.2 (20.8–27.4) | 89 | 28.5 | 1 | 63.4 | 1 | 0.21 |
| CYP3A4 | |||||||
| −392A>G | 22.9 (20.7–27.0) | 82 | 37.0 (15.0–50.4) | 9 | N/A | 0 | 0.05 |
| CYP3A5 | |||||||
| 6986A>G | 34.2 | 1 | 33.6 (18.6–42.6) | 12 | 22.9 (19.8–26.8) | 78 | 0.06 |
| ABCB1 | |||||||
| 1236C>T | 21.7 (15.3–29.6) | 24 | 24.7 (18.8–28.5) | 48 | 22.6 (16.4–31.0) | 17 | 0.91 |
| 2677G>T/Ac | 23.2 (18.1–29.7) | 25 | 25.2 (20.8–28.5) | 50 | 20.7 (15.0–48.5) | 15 | 0.88 |
| 3435C>T | 21.1 (14.5–29.6) | 19 | 26.4 (18.8–28.9) | 48 | 24.7 (18.6–28.4) | 23 | 0.38 |
| ABCC2 | |||||||
| −1019A>G | 27.1 (18.8–29.7) | 34 | 21.8 (18.6–28.5) | 43 | 21.0 (14.5–27.0) | 14 | 0.34 |
| −24C>T | 24.7 (21.1–28.5) | 61 | 21.7 (16.9–28.1) | 26 | 20.3 | 4 | 0.69 |
| 1249G>A | 23.6 (18.6–27.4) | 54 | 23.2 (17.3–29.2) | 33 | 35.8 | 2 | 0.62 |
| IVS26 –34T>C | 23.3 (20.8–27.4) | 82 | 24.8 (9.70–34.2) | 8 | 28.3 | 1 | 0.90 |
| 3972C>T | 24.0 (15.8–28.4) | 38 | 21.8 (18.1–27.5) | 41 | 27.6 (21.5–42.6) | 12 | 0.42 |
| 4544G>A | 23.4 (20.8–27.5) | 83 | 20.5 (9.70–73.9) | 6 | N/A | 0 | 0.61 |
N, number of patients; N/A, not available.
a
Data represent median clearance of docetaxel in units of l/h with range in the parentheses.
b
P values were obtained from a two-tailed Mann–Whitney U-test (two-group comparisons) or a Kruskal–Wallis test (multiple-group comparisons).
c
In the heterozygote group, 49 patients had the GT genotype and 1 had the GA genotype; in the variant group, 12 patients had the TT genotype and 3 had the TA genotype.