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9L cells overexpressing LRP generate CEST contrast in vitro. Rat 9L glioma cells stably expressing PEG-prom-driven LRP were generated to provide 9LPEG-LRP. a: In vitro CEST contrast in 9L vs. 9LPEG-LRP cells. b: The generalized estimating equation (GEE) approach demonstrated a difference in CEST contrast between wild-type and gene-tagged cells at 3.7 ppm, n = 3.
