Table 2.
CDKN2A fluorescence in-situ hybridization and p16 immunohistochemical results
| CDKN2A copy number | p16 IHC expressiona | |||
|---|---|---|---|---|
| Epithelium | Stroma | Epithelium | Stroma | |
| Benign Brenner tumors | ||||
| 1 | Disomy | Disomy | Diffuse | Focal |
| 2 | Disomy | Disomy | Diffuse | Focal |
| 3 | Disomy | Disomy | Diffuse | Focal |
| 4 | Disomy | Disomy | Patchy | Focal |
| 5 | Disomy | Disomy | Patchy | Focal |
| 6 | Disomy | Disomy | Patchy | Focal |
| 7 | Disomy | Disomy | Diffuse | Focal |
| 8 | Disomy | Disomy | Diffuse | Focal |
| 9 | Disomy | Disomy | Diffuse | Focal |
| 10 | Disomy | Disomy | Diffuse | Focal |
| 11 | Disomy | Disomy | Diffuse | Focal |
| 12 | Disomy | Disomy | Diffuse | Focal |
| 13 | Disomy | Disomy | Negative | Focal |
| Atypical proliferative Brenner tumors | ||||
| 1 | Homozygous deletion | Disomy | Negative | Focal |
| 2 | Homozygous deletion | Disomy | Negative | Focal |
| 3 | Homozygous deletion | Disomy | Negative | Focal |
| 4 | Homozygous deletion | Disomy | Negative | Focal |
| 5 | Homozygous deletion | Disomy | Negative | Focal |
| 6 | Homozygous deletion | Disomy | Negative | Focal |
| 7 | Homozygous deletion | Disomy | Negative | Focal |
Abbreviation: IHC, immunohistochemical.
a
p16 IHC expression is both cytoplasmic and nuclear.