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YAP promotes cancer cell survival and resistance to RAF-MEK-targeting agents. Shown is schematic of the role of YAP in BRAF- and RAS-mutant tumor cells and the potential integrative function of YAP in resistance to MAPK pathway inhibitors. YAP inhibition along with MAPK pathway inhibition enables complete anti-tumor response, in contrast to either YAP inhibition or MAPK pathway inhibition alone. MAPK, mitogen activated protein kinase; YAP, yes-associated protein.
