Figure 7.

Gene expression profiling of WT, p27KO and DKO thymuses identifies a p27KO signature reverted in DKO mice. (A) Gene microarray analysis of RNA extracted from thymus of C57BL/6 mice of the indicated genotypes. Six different WT and p27KO thymuses/genotype (3 males and 3 females) were probed on a 44K microarray slides to identify genes differentially expressed in WT versus p27KO thymus (p27KO signature). The p27KO signature was then compared to the gene expression profile of DKO thymus (3 males and 3 females). This comparison identified the DKO signature, representing the set of genes differentially regulated between WT and p27KO cells and reverted in DKO thymus.