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. 2015 Oct 20;5:15366. doi: 10.1038/srep15366

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Copyright © 2015, Macmillan Publishers Limited

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(A) Chromosome spread of control and Sirt6-MO MII oocytes. Chromosomes were stained with Hoechst 33342 (blue) and kinetochores were labeled with CREST (purple). Representative confocal images indicate (a) control oocytes with a normal haploid complement of 20 chromosomes, (b–c) Sirt6-MO oocytes with 21 chromosomes and premature separation of sister chromatids (yellow arrowhead). (B) Histogram showing the incidence of aneuploidy in control and Sirt6-MO oocytes. 50 control oocytes and 52 Sirt6-MO oocytes were analyzed respectively. Error bars indicate ± SD. *p < 0.05 vs. controls.