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Hsp90 is required for the stabilization of Gwl. (A) Xenopus egg extracts were prepared as described in Materials and Methods, and treated with or without Geldanamycin (2 μM). Extracts at indicated time points were analyzed by immunoblotting for Gwl, Cdc27, phospho-Cdk substrates, and H2B. (B) GST-Gwl was added into Xenopus egg extracts in either interphase or M-phase, and incubated overtime with Geldanamycin. Extract samples were analyzed by immunoblotting for GST.
