Table 1.

Comparison of key points between failed and successful clinical trials regarding endovascular treatment for acute ischemic stroke

Study name	Large artery occlusion	Infarct core/perfusion	Collateral criteria	Onset to puncture	Stent retriever	mTICI 2b/3	Ordinal shift mRS*
Previous failed clinical trials
IMS-3 [6]	N.R.	N.R.	N.R.	249 min	1.2%	41%	N.S.
SYNTHESIS Expansion [7]	N.R.	N.R.	N.R.	225 min	12.7%	N.A.	N.S.
MR RESCUE [8]	CTA or MRA	Core < 90 cc (> 1.43)†	N.R.	381 min	0%	27%	N.S.
Recent successful clinical trials
MR CLEAN [9]	CTA	N.R.	N.R.	260 min	82%	59%	1.7 (1.2-2.3)
ESCAPE [10]	CTA	NCCT, CBV or CBF ASPECTS ≥ 6	Good/moderate	185 min‡	86%	72%	2.6 (1.7-3.8)
SWIFT PRIME [11]	CTA or MRA	Core§ < 50 mL (> 1.8)†	N.R.	184 min‡	100%	88%	2.6 (1.6-4.4)
		NCCT ASPECTS ≥ 6
EXTEND IA [12]	CTA or MRA	Core∥ < 70 mL (> 1.2)†	N.R.	210 min	100%	86%	N.A.
REVASCAT [13]	CTA or MRA	NCCT ASPECTS ≥ 7	N.R.	269 min	100%	66%	1.7 (1.1-2.8)
		DWI ASPECTS ≥ 6

^*Common odds ratio;

^†Target mismatch ratio;

^‡Sum of median of parameters;

^§The ischemic core was assessed by MRI or CT;

^∥The ischemic core was defined by regional cerebral blood flow on CT perfusion or diffusion-weighted imaging.

mTICI, modified Thrombolysis in Cerebral Infarction; mRS, modified Rankin Scale; N.R., not required; N.S., not significant; N.A., not available; CTA, computed tomography angiography; NCCT, noncontrast computed tomomgraphy; CBV, cerebral blood volume; CBF, cerebral blood flow; MRA, magnetic resonance angiography.