Table 2.
G vs. A | GG vs. AA | GA vs. AA | GG vs. GA+AA | GG+GA vs. AA | ||||||
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MMP-12-82A/G | OR (95% CI) | P a | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P |
Overall | 1.09 (0.93-1.28) | 0.30 | 1.14 (0.78-1.67) | 0.48 | 1.06 (0.89-1.26) | 0.54 | 1.15 (0.79-1.68) | 0.46 | 1.08 (0.91-1.28) | 0.41 |
Ethnicity | ||||||||||
Asian | 1.15 (0.85-1.56) | 0.38 | 1.98 (0.32-12.09) | 0.46 | 1.15 (0.83-1.60) | 0.40 | 1.99 (0.33-12.16) | 0.46 | 1.15 (0.84-1.59) | 0.38 |
European | 1.00 (0.90-1.11) | 0.98 | 1.12 (0.76-1.64) | 0.58 | 0.97 (0.87-1.10) | 0.66 | 1.12 (0.76-1.65) | 0.55 | 0.99 (0.88-1.11) | 0.81 |
Source of control | ||||||||||
HB | 1.16 (0.96-1.41) | 0.13 | 1.10 (0.75-1.61) | 0.63 | 1.13 (0.92-1.40) | 0.24 | 1.11 (0.75-1.62) | 0.61 | 1.16 (0.94-1.42) | 0.17 |
PB | 0.89 (0.68-1.17) | 0.40 | 4.34 (0.48-38.88) | 0.19 | 0.83 (0.63-1.10) | 0.19 | 4.39 (0.49-39.32) | 0.19 | 0.86 (0.65-1.13) | 0.28 |
Cancer type | ||||||||||
Lung cancer | 1.21 (0.64-2.27) | 0.56 | 1.64 (0.17-15.48) | 0.66 | 1.03 (0.88-1.21) | 0.71 | 1.47 (0.19-11.32) | 0.72 | 1.16 (0.66-2.02) | 0.61 |
Colorectal cancer | 0.90 (0.71-1.15) | 0.41 | 1.18 (0.51-2.74) | 0.69 | 0.83 (0.63-1.11) | 0.21 | 1.24 (0.54-2.86) | 0.61 | 0.86 (0.65-1.13) | 0.28 |
Esophageal cancer | 0.87 (0.53-1.43) | 0.58 | 1.90 (0.47-7.69) | 0.37 | 0.85 (0.53-1.37) | 0.51 | 1.82 (0.45-7.35) | 0.40 | 0.86 (0.52-1.42) | 0.55 |
Gastric cancer | 1.10 (0.72-1.68) | 0.66 | - | - | 1.10 (0.72-1.70) | 0.66 | - | - | 1.10 (0.72-1.70) | 0.66 |
Ovarian cancer | 2.44 (1.45-4.08) | <0.01 | - | - | 2.50 (1.48-4.22) | <0.01 | - | - | 2.50 (1.48-4.22) | <0.01 |
Hepatocellular carcinoma | 0.92 (0.73-1.15) | 0.46 | 1.75 (0.57-5.30) | 0.33 | 0.85 (0.66-1.10) | 0.20 | 1.83 (0.60-5.54) | 0.29 | 0.88 (0.68-1.12) | 0.29 |
other cancer | 1.38 (0.75-2.53) | 0.30 | 3.08 (0.84-11.29) | 0.09 | 1.34 (0.66-2.73) | 0.42 | 3.06 (0.83-11.20) | 0.09 | 1.38 (0.70-2.72) | 0.35 |
OR odds ratio, CI confidence interval;
Random-effect model was used when P-value of Q-test for heterogeneity <0.05, otherwise fixed-effect model was used.