Table 2.

Stratified analysis of MMP-12-82A/G polymorphism and cancer risk

	G vs. A		GG vs. AA		GA vs. AA		GG vs. GA+AA		GG+GA vs. AA
MMP-12-82A/G	OR (95% CI)	P a	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P	OR (95% CI)	P
Overall	1.09 (0.93-1.28)	0.30	1.14 (0.78-1.67)	0.48	1.06 (0.89-1.26)	0.54	1.15 (0.79-1.68)	0.46	1.08 (0.91-1.28)	0.41
Ethnicity
Asian	1.15 (0.85-1.56)	0.38	1.98 (0.32-12.09)	0.46	1.15 (0.83-1.60)	0.40	1.99 (0.33-12.16)	0.46	1.15 (0.84-1.59)	0.38
European	1.00 (0.90-1.11)	0.98	1.12 (0.76-1.64)	0.58	0.97 (0.87-1.10)	0.66	1.12 (0.76-1.65)	0.55	0.99 (0.88-1.11)	0.81
Source of control
HB	1.16 (0.96-1.41)	0.13	1.10 (0.75-1.61)	0.63	1.13 (0.92-1.40)	0.24	1.11 (0.75-1.62)	0.61	1.16 (0.94-1.42)	0.17
PB	0.89 (0.68-1.17)	0.40	4.34 (0.48-38.88)	0.19	0.83 (0.63-1.10)	0.19	4.39 (0.49-39.32)	0.19	0.86 (0.65-1.13)	0.28
Cancer type
Lung cancer	1.21 (0.64-2.27)	0.56	1.64 (0.17-15.48)	0.66	1.03 (0.88-1.21)	0.71	1.47 (0.19-11.32)	0.72	1.16 (0.66-2.02)	0.61
Colorectal cancer	0.90 (0.71-1.15)	0.41	1.18 (0.51-2.74)	0.69	0.83 (0.63-1.11)	0.21	1.24 (0.54-2.86)	0.61	0.86 (0.65-1.13)	0.28
Esophageal cancer	0.87 (0.53-1.43)	0.58	1.90 (0.47-7.69)	0.37	0.85 (0.53-1.37)	0.51	1.82 (0.45-7.35)	0.40	0.86 (0.52-1.42)	0.55
Gastric cancer	1.10 (0.72-1.68)	0.66	-	-	1.10 (0.72-1.70)	0.66	-	-	1.10 (0.72-1.70)	0.66
Ovarian cancer	2.44 (1.45-4.08)	<0.01	-	-	2.50 (1.48-4.22)	<0.01	-	-	2.50 (1.48-4.22)	<0.01
Hepatocellular carcinoma	0.92 (0.73-1.15)	0.46	1.75 (0.57-5.30)	0.33	0.85 (0.66-1.10)	0.20	1.83 (0.60-5.54)	0.29	0.88 (0.68-1.12)	0.29
other cancer	1.38 (0.75-2.53)	0.30	3.08 (0.84-11.29)	0.09	1.34 (0.66-2.73)	0.42	3.06 (0.83-11.20)	0.09	1.38 (0.70-2.72)	0.35

OR odds ratio, CI confidence interval;

^aRandom-effect model was used when P-value of Q-test for heterogeneity <0.05, otherwise fixed-effect model was used.