Table 4.

Changes in creatinine clearance (ml/min)

Time	rhBNP group	Hydration group	P value
0 h	1.04±0.33	1.00±0.29	0.476
24 h	1.00±0.33	0.93±0.27	0.196
48 h	0.96±0.33	0.83±0.25	0.016*
72 h	1.01±0.40	0.88±0.27	0.019*

Repeated measure ANOVA showed that there were significant difference among the mean change of estimated glomerular filtration rate of four time points (F=64.340, P<0.001). There was significant difference in the interactive effect between time and group (F=13.305, P<0.001). All above results were corrected by using G-G.

^* P<0.05.

rhBNP: Recombinant human brain natriuretic peptide.