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. 2015 Jan 7;14(14):2367–2375. doi: 10.1080/15384101.2014.998067

Figure 3.

Figure 3.

BTK inhibition enhances sensitivity to bortezomib in bortezomib-naïve and bortezomib-resistant MM cells. (A) Relative cell viability of bortezomib-naïve and bortezomib-resistant MM cell lines 48 h post-ibrutinib 'pulse' treatment. (B) Relative cell viability of bortezomib-naïve and bortezomib-resistant MM cells post-ibrutinib 'pulse' treatment in combination with bortezomib (5 nM/24 h). (C) Relative cell viability of primary naïve and primary relapsed MM patient samples post in vitro ibrutinib 'pulse' treatment in combination with bortezomib (5 nM/24 h). Statistical significance between treatments was calculated by Student's t test; * indicates p ≤ 0.05. Statistical significance between cohorts was calculated by ANOVA; # indicates P ≤ 0.01.