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. 2015 Jan 7;14(14):2367–2375. doi: 10.1080/15384101.2014.998067

Figure 4.

Figure 4.

BTK inhibition via lenti-viral miRNA targeting enhances sensitivity to bortezomib in bortezomib-naïve and bortezomib-resistant MM cells. (A) qRT-PCR analysis of basal BTK mRNA expression in bortezomib-naïve and bortezomib-resistant MM U266 cells infected with lenti-viral miRNA constructs targeting BTK (miRBTK) transcription relative to GAPDH. (B) Relative cell viability of bortezomib-naïve and bortezomib-resistant MM U266 cells infected with lenti-viral miRBTK before and after bortezomib treatment (5 nM/24 h). Values indicate the mean ± SEM from 3 independent experiments. Statistical significance between treatments was calculated by Student's t test; * indicates P ≤ 0.05. Statistical significance between cohorts was calculated by ANOVA; # indicates p ≤ 0.01.