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COP1 induces p27 nuclear export. (A) Leptomycin B increased p27 nuclear accumulation in the presence of COP1. 293T cells co-transfected with either wild-type (wt) or NES mutant GFP-COP1 and RFP-p27, cultured with or without leptomycin B (LMB), were stained with DAPI. (B) Percentages of nuclear p27 signals among GFP-positive cells in A are shown.
