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COP1 overexpression leads to upregulation of p27-mediated suppressed genes. (A, B) COP1 regulated the genes that are suppressed through p27 mediation. COP1-overexpression or COP1 knockdown on gene expression of p27 target genes are shown. mRNA levels of the indicated p27 target genes were determined by quantitative reverse transcriptase PCR. (C) COP1 antagonized the suppressive impact of p27 on the expression of several targeted genes.
