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. 2015 May 6;14(14):2265–2273. doi: 10.1080/15384101.2015.1046655

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Figure 7. — COP1-p27 link correlates with poor survival. (A) COP1 overexpression in cancer led to increased expression of genes suppressed through p27 mediation. Relative expression of COP1 and genes suppressed through p27 mediation (COQ5, CDC123, GEMIN5, AURKA, KIF11, ING4, HEARTR1, and MED18) were analyzed from a data set of multiple myeloma samples. Data are presented as a heat map. (B) High expression of COP1 was associated with poor overall survival. Lysates of indicated multiple myeloma cells (RPMI8226) or ovarian cancer cells (2008) infected with either COP1-shRNA or control shRNA were analyzed by IB with the indicated antibodies. Kaplan-Meier overall survival curves for 414 patients with multiple myeloma (left) or ovarian cancer (right), classified by COP1 expression, are shown. (C) Protein levels of p27 were regulated according to COP1 expression in xenograft mouse models. HCT116 cells with CSN6 overexpression or knockdown were subcutaneously injected into the nude mice. Tumor samples were collected and lysates of indicated tumor samples were analyzed by IB with the indicated antibodies.