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. 2015 Mar 18;14(10):1568–1582. doi: 10.1080/15384101.2015.1026489

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Figure 7. — A model for the role of Lats1/2-CHO1-LIMK1 axis in preparation of cytokinesis initiation on centrosome. When Lats1/2-CHO1 axis is activated, LIMK1 is anchored to centrosomes by S716-phosphorylated CHO1, which in turn efficiently activates LIMK1 and promotes phosphorylation of Cofilin for preparation of cytokinesis initiation (right panel). If Lats1/2-CHO1 axis is not activated, CHO1 does not localize at centrosome, thereby decreasing the activating phosphorylation level and activation of LIMK1 to phosphorylate Cofilin (left panel). Eventually, dysregulation of Lats1/2-CHO1 axis fails to initiate cytokinesis.