Table 2.
Frequency of genotypes of the SNPs included in the study (n = 51 patients).
| Gene | SNP | Variant | Frequency (%) | Expected Frequency (%) * |
|---|---|---|---|---|
| ABCB1 | rs1045642 (3435 C > T) | CC | 39.2 | 27.1 |
| CT | 35.3 | 51.8 | ||
| TT | 25.5 | 21.1 | ||
| rs1128503 (1236 T > C) | CC | 47.0 | 32.5 | |
| CT | 37.3 | 49.8 | ||
| TT | 15.7 | 17.7 | ||
| rs2032582 (2677 G > T/A) | GG | 45.1 | 35.1 | |
| GT | 50.1 | 50.8 | ||
| TT | 4.8 | 12.1 | ||
| rs9282564 (61 A > G) | AA | 90.2 | 81.7 | |
| AG | 9.8 | 16.7 | ||
| GG | 0.0 | 1.7 | ||
| ABCC2 | rs3740066 (3972 C > T) | CC | 41.2 | 58.3 |
| TC | 41.2 | 35.7 | ||
| TT | 17.6 | 6.0 | ||
| rs2273697 (1249 G > A) | GG | 64.7 | 57.6 | |
| GA | 33.3 | 35.3 | ||
| AA | 2.0 | 7.1 | ||
| rs717620 (-24 C > T) | CC | 54.9 | 56.7 | |
| CT | 41.2 | 41.6 | ||
| TT | 3.9 | 1.7 | ||
| CYP3A5 | rs776746 (CYP3A5*3) | GA | 96.1 | 83.3 |
| GA | 3.9 | 15.7 | ||
| AA | 0.0 | 1.1 | ||
| NOD2/CARD15 | rs2066844 (R702W) | CC | 84.3 | 87.7 |
| CT | 15.7 | 11.8 | ||
| TT | 0.0 | 0.5 | ||
| SLCO1B1 | rs2306283 (SLCO1B1*1B) | AA | 43.7 | 40.1 |
| AG | 41.7 | 43.7 | ||
| GG | 15.6 | 16.2 | ||
| rs4149056 (SLCO1B1*5) | TT | 74.5 | 70.0 | |
| TC | 19.6 | 28.3 | ||
| CC | 5.9 | 1.7 | ||
| UGT1A9 | rs6714486 (-275T > A) | TT | 88.2 | 85.0 |
| TA | 11.8 | 15.0 | ||
| AA | 0.0 | 0.0 | ||
| rs17868320 (-2152 C > CT) | CC | 100.0 | 98.2 | |
| CT | 0.0 | 1.2 | ||
| TT | 0.0 | 0.0 |
* According to the Caucasian population (“dbSNP” database, http://www.ncbi.nlm.nih.gov/snp, accessed on March 2015).