Table 2.
The viscosity and texture parameters of HCT hydrogel containing various concentrations of HPMC in comparison with a marketed product (ELYZOL®).
| Formulation | Viscosity (cps) | Hardness (N) | Adhesiveness (N mm) | Compressibility (N mm) |
|---|---|---|---|---|
| TBO only a | 4.95 ± 0.37 | 0.13 ± 0.05 | 0.23 ± 0.03 | 0.56 ± 0.05 |
| Mixture of TBO & chitosan b | 4.59 ± 0.28 | 0.14± 0.02 | 0.25 ± 0.03 | 0.78 ± 0.03 |
| F-1 | 36.56 ± 1.50 | 0.18 ± 0.03 | 0.88 ± 0.03 | 1.46 ± 0.18 |
| F-2 | 46.64 ± 2.13 | 0.22 ± 0.02 | 1.89 ± 0.07 | 2.67 ± 0.59 |
| F-3 | 294.8 ± 20.6 | 0.56 ± 0.03 | 3.88 ± 0.12 | 5.33 ± 0.24 |
| F-4 | 495.4 ± 58.9 | 0.93 ± 0.06 | 6.07 ± 0.21 | 8.16 ± 0.49 |
| F-5 | 629.8 ± 113.6 | 1.67 ± 0.04 | 14.10 ± 0.33 | 13.89 ± 0.90 |
| ELYZOL® c | 187.4 ± 18.3 | 0.18 ± 0.02 | 0.95 ± 0.08 | 2.33 ± 0.49 |
a 20 μM TBO solution; b 20 μM TBO combined with chitosan (0.25%, w/w) in 1% acetic acid; c ELYZOL® is a topical antibiotic gel.