. 2015 Sep 10;16(9):21931–21949. doi: 10.3390/ijms160921931

Table 1.

Ratios of relative areas of nanofiber metabolites to control group.

Compound	Comparative Analysis
	CNF/Control		SDACNF/Control		Chitin/Control		CLNF/Control
	Ratio	p-Value	Ratio	p-Value	Ratio	p-Value	Ratio	p-Value
ATP	2.9	0.003	1.2	0.516	1.5	0.070	1.5	0.122
2,3-Diphosphoglyceric acid	2.7	0.003	1.1	0.805	1.5	0.238	1.5	0.277
ADP	2.2	0.003	1.1	0.678	1.4	0.201	1.3	0.346
5-Hydroxytryptophan	2.0	0.003	1.8	0.151	2.1	0.065	2.0	0.051
ADP-ribose	1.8	0.003	1.2	0.429	1.1	0.689	1.3	0.447
UTP	1.7	0.028	1.2	0.161	1.0	0.986	1.4	N.A.
Cystine	1.7	0.003	1.6	0.009	3.4	1.1 × 10⁻⁶	2.3	5.2 × 10⁻⁴
Serotonin	1.6	0.014	1.4	0.238	1.6	0.056	1.3	0.240
Urocanic acid	1.6	0.058	0.8	0.013	1.0	0.750	1.2	0.202
2,6-Diaminopimelic acid	1.5	0.043	1.1	N.A.	1.7	0.040	2.4	0.253
1-Methylhistamine	1.5	0.031	1.1	0.301	1.0	0.764	1.2	0.610
2-Aminoisobutyric acid	1.4	0.023	0.9	0.470	1.0	0.723	1.3	0.041
2-Hydroxyisobutyric acid	1.4	0.017	1.0	0.618	1.1	0.208	1.2	0.353
N⁵-Ethylglutamine	1.3	0.041	0.9	0.566	0.8	0.104	0.7	0.080
Thiamine	1.3	0.018	1.0	0.950	0.7	0.095	0.9	0.617
Putrescine	1.2	0.002	1.0	0.707	1.1	0.469	1.3	0.305
Trimethylamine N-oxide	1.1	0.696	1.6	0.013	1.4	0.238	2.2	0.109
N-Acetylglycine	1.1	0.324	0.9	0.040	1.0	0.721	1.2	0.054
FA(17:1)	0.9	0.544	0.7	0.022	0.7	0.013	0.9	0.253
Cystathionine	0.9	0.223	0.8	0.028	1.1	0.485	0.9	0.633
Stearic acid	0.9	0.349	0.8	0.033	0.8	0.016	0.9	0.353
Glycolic acid	0.8	0.026	1.0	0.864	1.0	0.826	1.0	0.934
Glu	0.8	0.038	0.8	0.101	0.8	0.031	0.8	0.042
Betaine	0.8	0.046	0.9	0.220	1.1	0.372	0.9	0.184
Argininosuccinic acid	0.7	0.027	0.7	0.024	0.6	0.005	0.8	0.429
AC(18:0)	0.7	0.007	0.6	0.002	0.5	4.9 × 10⁻⁴	0.8	0.140
Palmitoylcarnitine	0.7	0.138	0.4	0.019	0.4	0.020	0.7	0.221
AC(18:1)	0.6	0.080	0.4	0.019	0.5	0.029	0.8	0.525
AC(18:2)	0.5	0.015	0.4	0.008	0.5	0.013	0.8	0.431
Taurodeoxycholic acid	0.4	0.028	0.4	0.025	0.5	0.056	0.5	0.083
20α-Hydroxyprogesterone	0.4	0.013	0.7	0.176	0.8	0.375	0.9	0.734
Taurocholic acid	0.3	0.028	0.9	0.872	0.4	0.042	0.6	0.122

All the p-values were determined using Welch’s t-test. CNF, chitin nanofiber; SDACNF, surface-deacetylated CNF; CLNF, cellulose nanofiber; ATP, adenosine triphosphate; ADP, adenosine diphosphate; UTP, uridine triphosphate; Glu, glucose; N.A., not available.