Table 1.
Total manganese and nickel contents of rat’s organs, mcg per g of dried tissue, after repeated intraperitoneal injections of NiO or Mn3O4 nanoparticles, together or separately, and of their combination with background oral administration of the BPC (X ± s.e.).
| Metal | Groups of Rats Given (6 Rats) | ||||
|---|---|---|---|---|---|
| Control | NiO-NPs | Mn3O4-NPs | NiO-NPs + Mn3O4-NPs | NiO-NPs + Mn3O4-NPs and BPC | |
| Liver | |||||
| Manganese | 7.33 ± 0.56 | 6.33 ± 0.49 | 7.20 ± 0.73 | 6.80 ± 0.20 | 7.17 ± 0.31 |
| Nickel | 3.17 ± 0.65 | 16.40 ± 3.26 *,+,○ | 2.80 ± 0.20 + | 38.00 ± 2.80 * | 18.50 ± 1.56 *,+ |
| Spleen | |||||
| Manganese | 28.80 ± 1.74 | 32.00 ± 4.15 | 25.00 ± 1.87 | 25.83 ± 4.23 | 14.00 ± 2.33 *,+ |
| Nickel | 25.60 ± 1.89 | 46.75 ± 8.44 * | 32.50 ± 4.63 | 36.17 ± 7.21 | 36.25 ± 8.97 |
| Kidneys | |||||
| Manganese | 13.75 ± 0.95 | 10.00 ± 0.63 *,○ | 20.50 ± 1.45 *,+ | 10.80 ± 1.11 | 16.17 ± 1.62 + |
| Nickel | 18.20 ± 1.56 | 20.60 ± 3.23 | 16.00 ± 1.58 | 17.60 ± 1.29 | 18.67 ± 1.28 |
| Brain | |||||
| Manganese | 6.00 ± 0.45 | 7.17 ± 0.98 | 10.75 ± 1.70 * | 7.60 ± 1.08 | 9.20 ± 0.80 * |
| Nickel | 14.67 ± 0.96 | 12.83 ± 1.20 | 15.75 ± 2.46 | 15.80 ± 2.65 | 8.60 ± 0.60 + |
* statistically significant difference from the control group; + from the group given NiO-NPs + Mn3O4-NPs (without the BPC); ○ from the group given Mn3O4-NPs; (p < 0.05 by Student’s t-test with Bonferroni correction).