Table 2.
Total manganese and nickel renal excretion in rats after repeated intraperitoneal injections of NiO or Mn3O4 nanoparticles, together or separately, and of their combination with background oral administration of the BPC, mcg per 24 h (X ± s.e.).
| Metal | Groups of Rats Given | |||||
|---|---|---|---|---|---|---|
| Control (7 Rats) | NiO-NPs (8 Rats) | Mn3O4-NPs (8 Rats) | NiO-NPs + Mn3O4-NPs (7 Rats) | NiO-NPs + Mn3O4-NPs and BPC (7 Rats) | BPC (7 Rats) | |
| Manganese | 0.06 ± 0.05 | 0.008 ± 0.006 + | 0.06 ± 0.01 + | 0.52 ± 0.1 * | 0.28 ± 0.1 | 0.11 ± 0.1 |
| Nickel | 2.9 ± 0.2 | 37.9 ± 5.3 *,+,○ | 0.63 ± 0.3 *,+ | 16.7 ± 2.9 * | 40.8 ± 6.2 *,+ | 3.2 ± 0.3 |
* statistically significant difference from the control group; + from the group given NiO-NPs + Mn3O4-NPs (without the BPC); ○ from the group given Mn3O4-NPs; (p < 0.05 by Student’s t-test with Bonferroni correction).