Table 5.

Morphometric indices for the state of rat’s liver and spleen after repeated intraperitoneal injections of NiO or Mn₃O₄ nanoparticles, together or separately, and of their combination with background oral administration of the BPC (X ± s.e.).

Indices	Groups of Rats (4 Rats)
	Control	NiO-NPs	Mn3O4-NPs	NiO-NPs + Mn3O4-NPs	Nio-NPs + MN3O4-NPs + BPC
Liver
Akaryotic hepatocytes per 100 liver cells	2.73 ± 0.28	7.93 ± 0.51 *,+	6.03 ± 0.42 *	5.43 ± 0.41 *	3.38 ± 0.34 +
Binucleated hepatocytes per 100 liver cells	17.15 ± 0.66	14.33 ± 0.63 +	18.03 ± 0.60	18.40 ± 0.92	16.20 ± 0.72
Kupffer cells per 100 liver cells	11.25 ± 0.55	10.20 ± 0.63 +	12.75 ± 0.45 *,+	16.30 ± 1.22 *	12.2 ± 0.7 +
Spleen
Red pulp to white pulp ratio	8.3 ± 1.4	4.5 ± 0.9 *	5.2 ± 1.3	3.6 ± 0.4 *	6.2 ± 1.3 +
Number of brown pigment micro aggregates per square of the avtandilov’s grid	0	2.5 ± 0.2 ○	6.4 ± 0.3 *,+	10.4 ± 0.4 *	5.9 ± 0.2 *,+

* statistically significant difference from the control group; ⁺ from the group given NiO-NPs + Mn₃O₄-NPs (without the BPC); ^○ from the group given Mn₃O₄-NPs; (p < 0.05 by Student’s t-test with Bonferroni correction).