Meta-analysis of combination of laboratory and clinical makers in PE (both EOPE and LOPE). Legend: (1) PAPP-A, AFP, uE3, hCG (total or free β), inhibin-A; (2) mean PI + activin-A; (3) PlGF/sEng-ratio; (4) PAPP-A and free leptin index; (5) PP-13, UA-PI, AIx-75 (measure of arterial stiffness); (6) cystatin-C, CRP, uterine artery resistance index; (7) HbF ratio and A1M; (8) activin-A, inhibin-A, PlGF and UA-PI; (9) African American race, systolic blood pressure, BMI, education level, ADAM12, PAPP-A, PlGF; (10) BMI, education mother and HtrA1; (11) maternal characteristics, PlGF; (12) maternal characteristics, ADAM12; (13) maternal characteristics, PlGF; (14) sFLT-1, PlGF, PAPP-A, inhibin A, BMI, MAP; (15) PlGF, MAP, BMI, high fruit intake, uterine artery Doppler resistive index (UA-RI) * validation cohort; (16) PlGF, MAP, BMI, high fruit intake, UA-RI * training cohort.